The Atchison Santa Fe Freight Depot, built in 1880, is a masonry building constructed with quarry-faced ashlar stone of contrasting corner quoins and fenestration surrounds. The building has two main sections – a two-story office on the west end and a one-story freight section on the east. The building was nominated as part of the “Historic Railroad Resources of Kansas” multiple property nomination and is locally significant for its architecture and transportation history.